Egg Industry Center

Characterization of the Predisposing Factors of Pathogenesis of Focal Duodenal Necrosis in Egg Layers

Total Funded: $99,964
Project Duration: 30 months

The objectives of this study are to determine the predisposing factors for FDN and develop a challenge model using intestinal homogenates and C. perfringens isolates obtained from FDN lesions.

Focal Duodenal Necrosis (FDN) is not well understood within the United States. FDN has been seen in various states since 1997, affecting all varieties of flocks. FDN causes decreased egg production and lowered egg weights. Clear signs and symptoms do not always occur. Though FDN is a large problem, the cause is still unknown. Previous research has revealed that C. perfringens plays an important role in the development of FDN. This project will take a closer look at C. perfringens as a factor in predisposing birds to the disease.

The results of this study will create a better understanding of FDN, and aid in the development of control measures and intervention strategies to prevent FDN-associated losses. Through the challenge model, FDN can be reproduced, therefore allowing for the design and development of effective antibiotic-independent control methods.

The scientists from the University of Georgia working on this projects are: Dr. Monique S. França, Dr. Roy Berghaus, Dr. Charles L. Hofacre, and Dr. Margie Lee of the University of Georgia Poultry Diagnostic and Research Center; and Dr. Guillermo Zavala of Avian Health International.



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